Computer-aided tissue engineering of articular cartilage with physiological collagen architecture

Linda Kock, PhD

Mehdi Khosgoftar, PhD

The objective of this project is to engineer articular cartilage with improved biomechanical properties and a physiological arcade-like collagen network. A developed prototype bioreactor system is used to apply specific loading regimes, based on computations of strain distributions in a construct, in order to achieve an arcade-like collagen structure. The design of the bioreactor and the loading regime are iteratively optimized during the project, based on experimental results and computed predictions of the developing collagen network as a function of mechanical loading. These computations use advanced cartilage mechanics models in combination with algorithms for collagen remodeling. The ultimate results are an optimal loading strategy, a bioreactor that can apply required loading regime and a mechanically stable cartilage construct with a physiological collagen network.

The approach to integrate advanced biomechanical computer models with tissue engineering experiments to optimize the developing structure is innovative and very promising.

Link to dissertation

Kock, L.M. (2012). Strategies for engineering cartilage with improved content and organization. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr. K. Ito & dr. C.C. van Donkelaar).

Khoshgoftar, M. (2012). Computer-aided cartilage tissue-engineering : a numerical evaluation of the influence of inhomogeneities, collagen architecture and temporal culture effects. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr. K. Ito & dr. C.C. van Donkelaar).

This project is funded by STW