Tendon and Ligament Mechanobiology

Dr. Jasper Foolen

Tendon and ligament injuries are involved in over 30% of all musculoskeletal consultations. The poor innate regenerative capacity, controversy concerning adequate treatment and poor clinical outcome of surgical interventions, results in limited progress in the treatment of tendinopathy and connective tissue fibrosis/scarring over the past decades. Our goal is to explore mechanobiological processes that initiate degeneration and promote healing of tendon/ligament. Experimental platforms, e.g. biomimetic tendons/ligaments, are exploited in combination with numerical models to develop strategies to improve the structure and functionality of affected tendon/ligament.