Our group operates at the interface of chemical biology and synthetic biology. Combining protein engineering and DNA nanotechnology we develop intelligent biomolecular sensors and switches for applications in intracellular imaging, optogenetics, point-of-care diagnostics and antibody-based therapies.
FRET and BRET sensors for intracellular imaging
An important area of activity has been the development of fluorescent sensor proteins based on Förster Resonance Energy Transfer...Read more
Bioluminescent sensors for point-of-care diagnostics
A second line of research is the development of sensor proteins for point-of-care diagnostics. Using the same modular engineering...Read more
Protein sensing and actuation using DNA-based molecular circuits
DNA has emerged as a highly versatile construction material for nanometer-sized structures and sophisticated molecular machines...Read more