Bioluminescent sensors for point-of-care diagnostics
A second line of research is the development of sensor proteins for point-of-care diagnostics. Using the same modular engineering principles used in the development of FRET sensors for intracellular imaging, bioluminescent sensor proteins are developed that allow direct detection of antibodies and other biomarkers directly in complex matrices such as blood. Applications of this technology are explored in therapeutic drug monitoring and other areas where there is a need for simple, low-cost detection technology.
Key words: protein engineering, diagnostic assays, biosensors, infectious diseases, directed evolution, therapeutic antibodies, therapeutic drug monitoring
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