Workpackages and Milestones

WP1 – Scaffold Materials

Milestones:

  • Elastomeric scaffold material selected
  • Bioactive hybrid scaffold
  • Bioactive scaffold optimized

WP2 – Stent-scaffold interface and delivery system

Milestones:

  • Prototype stent and delivery system
  • Stent and valve attachment designed
  • Delivery system ready

WP3 – Initiation and early tissue formation

Milestones:

  • In vitro human host response and tissue initiation
  • Inter-individual effect on host response
  • Notch signaling and layered architecture

WP4 – Tissue homeostasis

Milestones:

  • Analysis of cell traction forces
  • Computational analysis of leaflet retraction

WP5 – Pre-clinical experiments

Milestones:

  • Short-term pre-clinical experiments
  • Medium-term pre-clinical experiments
  • Long-term pre-clinical experiments

WP6 – Regulatory issues and planning of FIM trial

Milestones:

  • Advice on standards by CAT
  • Regulatory submission dossier for FIM

WP7 – Dissemination and exploitation

Milestones:

  • Dissemination ready
  • Exploitation ready

WP8 – Project management

Milestones:

  • EU reports completed.