Workpackages and Milestones
WP1 – Scaffold Materials
WP2 – Stent-scaffold interface and delivery system
Milestones:
- Prototype stent and delivery system
- Stent and valve attachment designed
- Delivery system ready
WP3 – Initiation and early tissue formation
Milestones:
- In vitro human host response and tissue initiation
- Inter-individual effect on host response
- Notch signaling and layered architecture
WP4 – Tissue homeostasis
Milestones:
- Analysis of cell traction forces
- Computational analysis of leaflet retraction
WP5 – Pre-clinical experiments
Milestones:
- Short-term pre-clinical experiments
- Medium-term pre-clinical experiments
- Long-term pre-clinical experiments
WP6 – Regulatory issues and planning of FIM trial
Milestones:
- Advice on standards by CAT
- Regulatory submission dossier for FIM
WP7 – Dissemination and exploitation
Milestones:
- Dissemination ready
- Exploitation ready
WP8 – Project management
Milestones:
- EU reports completed.