dr. C.M. () Sahlgren - Expertise

Sahlgren, dr. C.M.
Address :
Technische Universiteit Eindhoven
P.O. Box 513
5600 MB EINDHOVEN
Department :
Department of Biomedical Engineering
Section :
Soft Tissue Biomechanics & Tissue Engineering
Positioncategory :
Associate Professor (UHD)
Position :
Associate Professor
Room :
GEM-Z 4.111
Tel :
+31 40-247 2761
Tel (internal) :
2761
Email :
C.M.Sahlgren@tue.nl

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Expertise

  • Cell and molecular biology
  • Stem cells
  • Cell tracking and molecular imaging
  • Nanotechnology for targeted drug delivery

Biography

Biography

Research Cell-cell communication in cardiac regeneration: Targeting the Notch signaling pathway The research aims at understanding the basic molecular principles of signaling mechanisms regulating cell fate choices of stem cells in cardiovascular tissue engineering. Another important goal is to develop technology to specifically monitor and tune these signals at will in specific cell populations, in order to steer stem cell fate and curtail disease activities. The key aims of the research are to:   1) Investigate how stem cells convert microenvironmental cues (biological, physical and chemical) into transcriptional processes that regulate stem cell fate during tissue regeneration. 2) Develop models and tools to study the crosstalk between the physical and chemical micro-environment and the transcriptional mechanisms regulating stem cell fate during tissue regeneration 3) Improve the outcome of stem cell therapy by manipulation of the stem cell microenvironment by rational control of physical and biological cues. 4) Identify novel disease mechanisms and therapeutic options targeting the stem cell /microenvironment interphase    The specific focus is the role and regulation of the evolutionary conserved Notch signaling pathway, a key regulator of stem cell function. The main objectives of our research are to understand i) how the cellular microenvironment influences Notch signaling activities and how this impinges on cell identity and function ii) how Notch activity in stem cells influence remodelling of the environment and to iii) develop technology platforms to regulate Notch signaling in engineered tissues and probes for cellular and molecular imaging. Increased knowledge of these processes can provide insights into regenerative processes and has the potential to find applications in material based stem cell therapy.