Maarten Merkx
Department / Institute
Group
RESEARCH PROFILE
Maarten Merkx is full professor at the department of Biomedical Engineering of Eindhoven University of Technology (TU/e), where he leads the research group Protein Engineering operating at the interface of chemical biology and synthetic biology. His research group combines approaches from protein engineering, chemical biology, and synthetic biology to develop biomolecular sensors and actuators for applications in intracellular imaging, point-of-care diagnostics, optogenetics, and antibody-based therapies. An important research theme is the engineering of biomolecular switches, which include fluorescent and bioluminescent sensor proteins for intracellular imaging, photo-switchable proteins, and protein- and DNA-based sensors for antibody detection and actuation.
Proteins are highly efficient and sophisticated macromolecular machines that run life. By engineering new proteins with new functions we go beyond the already impressive functional diversity of natural proteins, critically testing our understanding of protein function and developing new applications for proteins in therapy and diagnosis.
ACADEMIC BACKGROUND
Maarten Merkx studied physical organic chemistry and biochemistry at the Radboud University Nijmegen (1995, cum laude). He did his PhD with Prof. Averill (1999, University of Amsterdam) working on purple acid phosphatases, and was an HSFP post-doctoral fellow with Prof. Lippard (MIT, 1999-2001). Currently he is a professor in protein engineering at the Eindhoven University of Technology, a core member of the Institute for Complex Molecular Systems (ICMS) and dean of the department of Biomedical Engineering.
He obtained young investigator grants from NWO (VIDI 2006), an ERC Consolidator grant in 2011, and an ERC Proof of Concept grant in 2014 and 2017. As the only Dutch scientist he was invited in 2015 to speak at the World Economic forum in a session on the future of synthetic biology. In 2017 he reached the media with his expertise on DNA computing, amongst others an article on wired.com. In 2019 he received an NWO Take Off grant to map the commercial possibilities of his glow-in-the-dark paper-based assays for point-of-care diagnostics. Furthermore, he was awarded multiple times as best teacher in the master’s program, and received the award for the best TU/e teacher at the master level in 2012. In November 2019, he became the dean of the TU/e department of Biomedical Engineering.
Recent Publications
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Eva A. van Aalen,Benice van Gerven,Yan Ni,Remco Arts,Maarten Merkx
Turning Antibodies into Ratiometric Bioluminescent Sensors for Competition-Based Homogeneous Immunoassays
ACS Sensors (2024) -
Yosta de Stigter,Harmen J. van der Veer,Bas J.H.M. Rosier,Maarten Merkx
Bioluminescent Intercalating Dyes for Ratiometric Nucleic Acid Detection
ACS Chemical Biology (2024) -
Alexander Gräwe,Cindy M. Spruit,Robert P. de Vries,Maarten Merkx
Bioluminescent detection of viral surface proteins using branched multivalent protein switches
RSC Chemical Biology (2024) -
Lieuwe Biewenga,Robin Vermathen,Bas J.H.M. Rosier,Maarten Merkx
A Generic Antibody-Blocking Protein That Enables pH-Switchable Activation of Antibody Activity
ACS Chemical Biology (2024) -
Yi Sheng Lu,Ruhan Fan,Lieuwe Biewenga,Ziming Zhou,Sanahan Vijayakumar,Maarten Merkx,Michael J. Sailor
Harnessing the Materials Chemistry of Mesoporous Silicon Nanoparticles to Prepare “Armor-Clad” Enzymes
Chemistry of Materials (2023)
Current Educational Activities
Ancillary Activities
- Associate Editor ACS Sensors, American Chemical Society
- wetenschappelijk adviseur, LUMABS BV
- Raad van advies, Fontys Applied Natural Sciences
- bestuur, Raad van Bestuur SBMC
- lid raad van toezicht, Stichting Big Chemistry
- Lid raad van toezicht, Stichting Dutch Cardiovascular Alliance (DCVA)