Controlled release of Capreomycin sulphate from pH-responsive nanocapsules


Loiko, O., Herk, van, A.M., Ali, S.I., Burkeev, M.Zh., Tazhbayev, Y.M. & Zhaparova, L. (2013). Controlled release of Capreomycin sulphate from pH-responsive nanocapsules. e-Polymers, 13(1), 189-202.

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The synthesis of polymeric nanocapsules loaded with the antituberculosis drug Capreomycin sulfate is presented in this work. The pH-responsive polymeric nanocapsules were successfully synthesized using the RAFT-based vesicle templating approach described earlier in the presence of capreomycin sulfate. Anionic small polyelectrolytes comprising randomly distributed Bu acrylate and acrylic acid units were adsorbed on cationic vesicles of dimethyldioctadecyl ammonium bromide (DODAB). N,N-(dimethylamino)ethyl methacrylate (DMAEMA) and Me methacrylate (MMA) or tert-Bu methacrylate (tBMA) and MMA were used for the formation of the polymeric shells. Subsequently the tBMA was hydrolyzed to obtain neg. charged nanocapsules. The nanocapsule morphol. for both approaches was characterized by DLS and TEM. The most stable hollow latex particles were obtained with the monomer compn. of DMAEMA:MMA = 1:1. These nanocapsules were found to be colloidally stable and pH-responsive. The entrapment efficiency of drug detd. by UV-Vis-spectroscopy was 70%. The drug release rate from nanocapsules at pH 6.5 was found to be relatively fast (substantial release within one hour already), however we believe slower release can be achieved by using a thicker polymer shell.