A step forward in NoC technology
Rahman Sabahi Kaviani defended his PhD thesis at the Department of Mechanical Engineering on January 17th.
Within his PhD research Rahman Sabahi Kaviani introduced components which provide researchers and developers with a powerful set of tools to study how neuronal cells behave and interact in different scenarios. This opens exciting possibilities for various applications, advancing our understanding of neurology and aiding in the development of innovative disease models. Overall, this work has the potential to create effective solutions for treating neurodegenerative diseases, improving the quality of life for those affected, and reducing the societal burden associated with these conditions.
Every day, millions of people around the world struggle with the devastating impact of neurodegenerative diseases such as Parkinson's and Alzheimer's. These conditions not only affect individuals but also place immense strain on families and healthcare systems. Understanding and treating these complex disorders has proven to be a substantial challenge, given the intricate nature of the human nervous system and brain. However, groundbreaking research on Nervous system-on-Chip (NoC) technology holds the promise of hope in finding new therapeutic opportunities. Imagine a microscopic world where we can closely mimic the complexity of the human nervous system's environment on a tiny chip. This is precisely what NoC technology aims to achieve by combining advancements in microfluidics and tissue engineering. The goal is to create a platform that allows us to better understand these neurological disorders and develop effective treatments.
New insights behavior cells
The research of Sabahi Kaviani explores the details of NoC technology, investigating how we can fabricate, characterize, and integrate its components. Microscale devices, such as microtunnel devices, microsieves, and nanogrooves, are designed and fabricated using cutting-edge techniques. These components form a toolbox, providing researchers with a diverse set of capabilities to investigate how neurons grow and interact. Moreover, the deployment of advanced manufacturing techniques allows for creating a controlled and precise environment. For example, the use of laser technology enhances the precision of 3D micropores in microsieves. The designed structures influence how cells experience mechanical stress, paving the way for new insights into their behavior.
Access to neural network models
The introduction of neurons into microfabricated devices streamlines access to neural network models. This allows scientists to explore how the NoC microenvironment influences network behavior, uncovering new aspects of neuroelectrophysiology. This study has also demonstrated the remarkable potential of electrically functionalized polymer-based microsieves, where thin film electrodes and wiring patterns have been successfully integrated. This development enables the recording of neural activity on microsieves, providing insights into the electrical features of brain function.
In summary this PhD research explores the innovative Nervous system-on-Chip (NoC) technology, utilizing micro- and nanofabrication techniques and microfluidics. Key findings include the development, fabrication, and characterization of diverse NoC components and 3D microenvironment for neuronal cell cultures, as well as showcasing electrical assessment of neural activity. These technical advancements contribute to a modular NoC toolbox, enhancing our understanding of neurophysiology and supporting the development of effective solutions for treating neurodegenerative diseases.
The research is part of European Union’s Horizon 2020 CONNECT project.
Title of PhD thesis: Development of Nervous System-on-Chip Technology. Supervisors: Dr. Regina Luttge, and Prof. Jaap den Toonder.