My overarching goal is to institutionalize nanotechnologies for precision immunotherapy and immuno-imaging. In addition to making such precision medicine approaches available to patients, I strive to cultivate a unique research environment for the next generation of biomedical engineers.
Willem Mulder is professor of Precision Medicine at the department of Biomedical Engineering. His main affiliation is with Mount Sinai’s Translational and Molecular Imaging Institute (TMII, Icahn School of Medicine, New York, USA) where he is a professor of Radiology and Oncological Sciences. His research focuses on precision imaging and targeted therapy in cardiovascular disease, cancer and transplantation. Mulder has established library technology, encompassing nanomaterials derived from natural lipoproteins, which allows meticulously designing nano-immunotherapies. When appropriately designed, such nano-immunotherapies can be applied to empower the immune system’s ability to fight disease, by promoting or inhibiting an immune response, by polarizing macrophage function, or by targeting myeloid cell dynamics. Concurrently, Mulder’s team develops methods that allow imaging immune response with high precision and non-invasively. Recently Mulder and co-workers presented the results of research regarding a mouse transplantation model where their nano-immunotherapy spectacularly promotes organ acceptance without the need for chronic immunosuppression in the journal 'Immunity'.
Willem Mulder obtained his MSc in Chemistry from Utrecht University (the Netherlands) in 2001 and his PhD in Biomedical Engineering from Eindhoven University of Technology (TU/e, the Netherlands) in 2006. Thereafter, he was appointed assistant professor of Radiology at Mount Sinai’s Translational and Molecular Imaging Institute (TMII, Icahn School of Medicine at Mount Sinai, New York, USA) where he founded the Nanomedicine Laboratory. In 2012 he was appointed associate professor and in 2016 full professor of Radiology at Mount Sinai. In 2013, he received a Vidi grant by the Netherlands Organisation of Scientific Research (NWO) and was appointed as part-time professor of ‘Cardiovascular Nanomedicine' at the Academic Medical Center of the University of Amsterdam. In 2018, he was awarded a 1,5 million euro Vici grant by the Netherlands Organisation of Scientific Research NWO. He then moved to Eindhoven University of Technology (TU/e) to start his research group as professor of Precision Medicine at the TU/e department of Biomedical Engineering.
Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple speciesScience Translational Medicine (2019)
Therapeutic targeting of trained immunityNature Reviews Drug Discovery (2019)
Nanoimmunotherapy to treat ischaemic heart diseaseNature Reviews. Cardiology (2019)
Inhibiting inflammation with Myeloid cell-specific nanobiologics promotes organ transplant acceptanceImmunity (2018)
Nanoemulsion-based delivery of fluorescent PARP inhibitors in mouse models of small cell lung cancerBioconjugate Chemistry (2018)
Current Educational Activities
- Professor of Radiology / Director Nanomedicine Program, Icahn School of Medicine at Mount Sinai