8W130 - Tissue engineering


  • Introduction to tissue engineering: definition and historical prespective
  • Limitations of existing biomaterials solutions. Highlighting the important medical needs.
  • Cell biology
  • cell types, stem cells, intracellular structures (membrane, cytoskeleton, nucleus) important signalling molecules
  • Biochemistry and concept of molecular biology
  • Cell growth and differentiation pathways, mechanisms and control, extracellular matrix, epithelial mesenchymal interactions, matrix molecules and their ligands, gene expression, concept of mechanotransduction.
  • In vitro control of tissue development
  • cell culture and specific needs for different cell types, growth factors, models for tissue engineering, physical characteristics for transplantation, cell function in constructs; influence of mechanical, chemical and extracellular matrix environment.
  • Construct Technology
  • 3-D structure, multi-cellular systems, transport of nutrients and metabolites in tissue engineering, bioreactors for tissue engineered constructs, preservation of tissue engineered constructs
  • Clinical applications - anatomy, physical and biological characterisation, cirtique of tissue engineered products
  • skin, cardiovascular substitutes, cartilage, bone, ligaments/tendons
  • Tissue Engineering Industry
  • future prospects for growth, worldwide perspective, regulatory affairs FDA

Learning objectives

  • Understand the multidisciplinary principles underpinning tissue engineering
  • Appreciate scientific principles that underlie a series of strategies to repair specific tissues
  • Appreciate challenges associated with tissue engineering industry.