The intriguing capacity of living cells to shape and adapt their own environment teaches us how to engineer new tissues for the heart.
Carlijn Bouten is professor of Cell-Matrix Interactions in Cardiovascular Regeneration at the department of Biomedical Engineering (research group Soft Tissue Engineering & Mechanobiology). Her research group investigates the interplay between living cells and the mechanobiological cues originating from the extracellular matrix under conditions of tissue growth, adaptation, and regeneration and degeneration. The group uses ‘living’ model systems at different length scales (cell, cell-matrix, engineered tissue, native tissue) to quantify these aspects, preferably in real-time. The obtained knowledge is applied in engineering approaches to regenerate living tissues, in particular for the human heart. A prominent example is the development of a synthetic, biodegradable heart valve prosthesis that seduces the body to create a new, living heart valve at the site of implantation. Bouten performs her multidisciplinary research in close collaboration with material scientists, life scientists, clinicians, and medtech spin-offs. She leads several national and international public-private-patient research consortia in the field of Regenerative Medicine and Tissue Engineering.
Carlijn Bouten was trained in functional anatomy and biomechanics as well as muscle physiology at the department of Human Movement Sciences of Vrije Universiteit Amsterdam, where she received her MSc degree in 1991. In 1995, she obtained her PhD degree from Eindhoven University of Technology (TU/e, the Netherlands). She performed postdoctoral research at the Université Laval (Quebec), University of London, and at TU/e. In 1998, she was appointed assistant professor in Cellular Biomechanics in the department of Mechanical Engineering at TU/e, and in 2002 she became associate professor of Tissue Engineering in the department of Biomedical Engineering at the same university. In 2010, Carlijn Bouten was appointed full professor of Cell-Matrix Interaction in Cardiovascular Regeneration at TU/e. She is a recipient of the Aspasia Career Development award of the Dutch Science Foundation NWO (2002), which awarded her a VICI grant for her research on heart valve tissue engineering in 2003. From 2005-2010 Bouten was member of The Young Academy of the Royal Netherlands Academy of Arts and Sciences (KNAW).Since 2017, she leads the national gravitation program Materials-Driven Regeneration. In that same year she was elected member of the KNAW.
Mechanobiology of the cell–matrix interplay: catching a glimpse of complexity via minimalistic modelsExtreme Mechanics Letters (2018)
Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasisProceedings of the National Academy of Sciences of the United States of America (2018)
Spatial patterning of the Notch ligand Dll4 controls endothelial sprouting in vitroScientific Reports (2018)
Modulation of macrophage phenotype and protein secretion via heparin-IL-4 functionalized supramolecular elastomersActa Biomaterialia (2018)
Emergence of a geometrical and mechanical equilibrium in tissue-engineered heart valves?Annual Heart Valve Society meeting 2018 (2018)
- Bachelor final project Soft Tissue Engineering and Mechanobiology
- BMT Science class: Prof. Bouten
- Heart and blood
- Board of Directors Heart Valve Society, Heart Valve Society (internationaal)
- Bezit aandelen als lid van STAK, Xeltis AG (spin-off van de TU/e)
- Lid van de wetenschappelijke adviesraad, Hartstichting