Miguel Dias Castilho
Department / Institute
Group
RESEARCH PROFILE
Development of design & fabrication technologies that enable the local control of (bio) material composition and structure across multiple length scales is fundamental to understand complex regenerative processes in the human body; as well as to develop approaches for functional restoration of damaged&diseased tissues and organs. To address this challenge, Castilho team uses a material-by-design approach, combining advanced 3D printing technologies and computational design, to develop instructive materials for regenerative medicine, particularly of musculoskeletal tissues, like bone. Castilho’s research is interdisciplinary, bringing together engineers, materials scientists and cell biologists. An important focus area of the team is on exploring opportunities for translation of instructive materials in human clinics.
ACADEMIC BACKGROUND
Miguel Castilho is an Assistant Professor of Biomaterials design and processing at TU/e. He holds a MSc degree in Mechanical Engineering and a PhD in Biomedical engineering (cum laude) from the University of Lisbon (IST, Portugal). During his PhD studies he was a visiting researcher at Department for Functional Materials in Medicine and Dentistry, University of Würzburg (Germany), in the field of Bioactive inorganic materials design and 3D printing. From 2015 - 2018 he was a post-doctoral research fellow in 3D Printing and Biofabrication at the University Medical Center Utrecht (UMC Utrecht, The Netherlands), to become an Assistant professor at UMC Utrecht and at the Regenerative Medicine Center (The Netherlands) from 2018 – 2021. In 2021 he started a tenured position as an Assistant Professor in the Department of Biomedical Engineering at TU/e, and holds an adjunct appointment in Biofabrication at UMC Utrecht.
Recent Publications
-
Gerardo Cedillo-Servin,Ouafa Dahri,João Meneses,Joost van Duijn,Harrison Moon,Fanny Sage,Joana Silva,André Pereira,Fernão D. Magalhães,Jos Malda
3D Printed Magneto-Active Microfiber Scaffolds for Remote Stimulation and Guided Organization of 3D In Vitro Skeletal Muscle Models
Small (2024) -
Martina Viola,Madison J Ainsworth,Marko Mihajlovic,Gerardo Cedillo-Servin,Mies J van Steenbergen,Mattie van Rijen,Mylène de Ruijter,Miguel Castilho,Jos Malda,Tina Vermonden
Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructs
Biomacromolecules (2024) -
Ricardo M. Rosales,Konstantinos A. Mountris,Aida Oliván-Viguera,María Pérez-Zabalza,Gerardo Cedillo-Servin,Olalla Iglesias-García,Andrei Hrynevich,Miguel Castilho,Jos Malda,Felipe Prósper
Experimentally-guided in silico design of engineered heart tissues to improve cardiac electrical function after myocardial infarction
Computers in Biology and Medicine (2024) -
Niclas Flosdorf,Janik Böhnke,Marcelo A.S. de Toledo,Niklas Lutterbach,Vanesa Gómez Lerma,Martin Graßhoff,Kathrin Olschok,Siddharth Gupta,Vithurithra Tharmapalan,Susanne Schmitz
Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche
Stem cell reports (2024) -
Yuanyuan Han,Renan Dal-Fabbro,Abdel H. Mahmoud,Maedeh Rahimnejad,Jinping Xu,Miguel Castilho,Waruna L. Dissanayaka,Marco C. Bottino
GelMA/TCP nanocomposite scaffold for vital pulp therapy
Acta Biomaterialia (2024)
Current Educational Activities
Ancillary Activities
- Adjunct Assistant professor, University Medical Center Utrecht, The Netherlands
- Member of Scientific Leadership Committee, International Society of Bone Morphometry