Hydrogels are widely used for generating cell-loaded tissue-like constructs in vitro, but they cannot entirely approximate the diverse range of complex mechanical environments in native tissue, especially in tissue engineering applications that require mechanical support and complex anisotropic organization and properties. Thus, hydrogel reinforcement with 3D-printed fibers offers a promising approach. This project leverages the controlled layer-by-layer deposition of microfibers from natural and synthetic polymers to generate highly porous scaffolds with complex geometries. With this method, we aim to create bioresorbable scaffolds that incorporate sophisticated metamaterial functionality to overcome mechanical limitations in regenerative stents, as well as controlled micro-architectures that guide cell organization and collective contractility in cardiac patches for cell therapy against myocardial infarction. Moreover, stimuli-responsive microfiber scaffolds have high surface area and tunable porosity, which allow for localized controlled drug release triggered by external signals.