Project of Biomaterials Design & Processing

Geometry-mediated bone formation

Geometry-driven osteoinduction enabled by high speed, high precision additive manufacturing.

Despite the current lack of consensus among researchers regarding the specific mechanisms behind osteoinduction, there are indications that the geometry and architecture of a scaffold play a significant role, alongside biological and chemical cues. To address these challenges, our approach involves developing a volumetric additive manufacturing process that facilitates the rapid and reproducible production of biomimetic scaffolds. Employing this technology, we aim to systematically manipulate the scaffold's architecture to investigate the influence of geometry on the material's osteoinductive properties. We thereby seek to contribute to the understanding of how scaffold architecture impacts osteoinduction and advancing the development of synthetic bone grafts with enhanced regenerative capabilities.