Osteoarthritis and Cartilage Tissue Engineering
Degenerative joint disease, another common musculoskeletal disease, is believed to be a result of disturbed balance between strength of articular cartilage, joint loading, and lack of biological repair.
Degenerative joint disease, another common musculoskeletal disease, is believed to be a result of disturbed balance between strength of articular cartilage, joint loading, and lack of biological repair. Computational and in vitro models are used to delineate its cause and pathogenesis. Once damaged or degraded, surgical intervention is often necessary. Cartilage regeneration is an attractive treatment method in such interventions. Unfortunately current methods could be much improved. We believe that proper tissue conditioning can result in better tissue ultrastructure and function. Using a multidisciplinary approach, computational models are used to optimize tissue conditions and combined with in vitro experiments for model development, validation and final proof of concepts studies.